Proteomic analysis reveals exercise training induced remodelling of hepatokine secretion and uncovers syndecan-4 as a regulator of hepatic lipid metabolism

• Autori principali: William De Nardo (Autore), Paula M. Miotto (Autore), Jacqueline Bayliss (Autore), Shuai Nie (Autore), Stacey N. Keenan (Autore), Magdalene K. Montgomery (Autore), Matthew J. Watt (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2022-06-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Objective: Non-alcoholic fatty liver disease (NAFLD) is linked to impaired lipid metabolism and systemic insulin resistance, which is partly mediated by altered secretion of liver proteins known as hepatokines. Regular physical activity can resolve NAFLD and improve its metabolic comorbidities, howe...