Ibrutinib Inhibits Angiogenesis and Tumorigenesis in a BTK-Independent Manner

• Main Authors: Jia Liu (Author), Zhuojun Liu (Author), Jing Zhang (Author), Xiaofang Chen (Author), Junge Chen (Author), Linlin Sui (Author), Jian Yu (Author)
• Format: Book
• Published: MDPI AG, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BTK inhibitor (BTKi) Ibrutinib carries an increased bleeding risk compared to more selective BTKis Acalabrutinib and Zanubrutinib, however, its impact on vascular endothelium remains unknown. In this study, we found that Ibrutinib induced stronger cytotoxic effect on endothelial cells than Zanubruti...