Quantitative assessment of translocator protein (TSPO) in the non-human primate brain and clinical translation of [18F]LW223 as a TSPO-targeted PET radioligand

• Main Authors: Zhiqiang Tan (Author), Ahmed Haider (Author), Shaojuan Zhang (Author), Jiahui Chen (Author), Junjie Wei (Author), Kai Liao (Author), Guocong Li (Author), Huiyi Wei (Author), Chenchen Dong (Author), Wenqing Ran (Author), Ying Li (Author), Yuefeng Li (Author), Jian Rong (Author), Yinlong Li (Author), Steven H. Liang (Author), Hao Xu (Author), Lu Wang (Author)
• Format: Book
• Published: Elsevier, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Translocator protein 18 kDa (TSPO) positron emission tomography (PET) can be harnessed for the non-invasive detection of macrophage-driven inflammation. [18F]LW223, a newly reported TSPO PET tracer which was insensitive to rs6971 polymorphism, showed favorable performance characteristics...