Sirt3 Mediates the Inhibitory Effect of Adjudin on Astrocyte Activation and Glial Scar Formation following Ischemic Stroke

• Główni autorzy: Xiao Yang (Autor), Keyi Geng (Autor), Jinfan Zhang (Autor), Yanshuang Zhang (Autor), Jiaxiang Shao (Autor), Weiliang Xia (Autor)
• Format: Książka
• Wydane: Frontiers Media S.A., 2017-12-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

In response to stroke-induced injury, astrocytes can be activated and form a scar. Inflammation is an essential component for glial scar formation. Previous study has shown that adjudin, a potential Sirt3 activator, could attenuate lipopolysaccharide (LPS)- and stroke-induced neuroinflammation. To i...