A physiologically based pharmacokinetic model of cefepime to predict its pharmacokinetics in healthy, pediatric and disease populations

• Main Authors: Muhammad Talha Zahid (Author), Ammara Zamir (Author), Abdul Majeed (Author), Imran Imran (Author), Sary Alsanea (Author), Tanveer Ahmad (Author), Faleh Alqahtani (Author), Muhammad Fawad Rasool (Author)
• Format: Book
• Published: Elsevier, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The physiologically based pharmacokinetic modeling (PBPK) approach can predict drug pharmacokinetics (PK) by combining changes in blood flow and pathophysiological alterations for developing drug-disease models. Cefepime hydrochloride is a parenteral cephalosporin that is used to treat pneumonia, se...