Prime-boost-type PspA3 + 2 mucosal vaccine protects cynomolgus macaques from intratracheal challenge with pneumococci

• Main Authors: Chieko Yokota (Author), Kosuke Fujimoto (Author), Natsuko Yamakawa (Author), Masamitsu Kono (Author), Daichi Miyaoka (Author), Masaki Shimohigoshi (Author), Miho Uematsu (Author), Miki Watanabe (Author), Yukari Kamei (Author), Akira Sugimoto (Author), Natsuko Kawasaki (Author), Takato Yabuno (Author), Tomotaka Okamura (Author), Eisuke Kuroda (Author), Shigeto Hamaguchi (Author), Shintaro Sato (Author), Muneki Hotomi (Author), Yukihiro Akeda (Author), Ken J. Ishii (Author), Yasuhiro Yasutomi (Author), Kishiko Sunami (Author), Satoshi Uematsu (Author)
• Format: Book
• Published: BMC, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Although vaccination is recommended for protection against invasive pneumococcal disease, the frequency of pneumococcal pneumonia is still high worldwide. In fact, no vaccines are effective for all pneumococcal serotypes. Fusion pneumococcal surface protein A (PspA) has been show...