Repeated Administration of Clinical Doses of Tramadol and Tapentadol Causes Hepato- and Nephrotoxic Effects in Wistar Rats

• Main Authors: Joana Barbosa (Author), Juliana Faria (Author), Fernanda Garcez (Author), Sandra Leal (Author), Luís Pedro Afonso (Author), Ana Vanessa Nascimento (Author), Roxana Moreira (Author), Odília Queirós (Author), Félix Carvalho (Author), Ricardo Jorge Dinis-Oliveira (Author)
• Format: Book
• Published: MDPI AG, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tramadol and tapentadol are fully synthetic and extensively used analgesic opioids, presenting enhanced therapeutic and safety profiles as compared with their peers. However, reports of adverse reactions, intoxications and fatalities have been increasing. Information regarding the molecular, biochem...