Novel hydroxyl carboximates derived from β-elemene: design, synthesis and anti-tumour activities evaluation

• Main Authors: Yuan Gao (Author), Nian-Dong Mao (Author), Hao Che (Author), Li Xu (Author), Renren Bai (Author), Li-Wei Wang (Author), Xiang-Yang Ye (Author), Tian Xie (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of novel N-alkyl-N-hydroxyl carboximates derived from β-elemene were fortuitously discovered. Most of them showed more potent anti-proliferative activities than their lead compound β-elemene (1). Notably, compound 11i exhibited significant inhibitory effects on the proliferation of three lu...