Population pharmacokinetic analysis of apomorphine sublingual film or subcutaneous apomorphine in healthy subjects and patients with Parkinson's disease

• Main Authors: Felix Agbo (Author), Ryan L. Crass (Author), Yu‐Yuan Chiu (Author), Sunny Chapel (Author), Gerald Galluppi (Author), David Blum (Author), Bradford Navia (Author)
• Format: Book
• Published: Wiley, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Apomorphine is an on‐demand treatment of "OFF" episodes in patients with Parkinson's disease (PD). A joint parent‐metabolite population pharmacokinetic (PK) model characterized apomorphine and apomorphine‐sulfate following administration of apomorphine sublingual film (APL) a...