Studying the Effect of Amino Acid Substitutions in the M2 Ion Channel of the Influenza Virus on the Antiviral Activity of the Aminoadamantane Derivative In Vitro and In Silico

• मुख्य लेखकों: Timur Mansurovich Garaev (लेखक), Artyom Irorevich Odnovorov (लेखक), Alexander Aleksandrovich Lashkov (लेखक), Tatiana Vladimirovna Grebennikova (लेखक), Marina Pavlovna Finogenova (लेखक), Galina Kadymovna Sadykova (लेखक), Alexei Gennadievich Prilipov (लेखक), Tatiana Anatol'evna Timofeeva (लेखक), Sergey Vadimovich Rubinsky (लेखक), Svetlana Nikolaevna Norkina (लेखक), Marina Mikhailovna Zhuravleva (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Tabriz University of Medical Sciences, 2021-09-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Purpose: The aminoadamantane derivative of L-histidyl-1-adamantayl ethylamine hydrochloride (HCl*H-His-Rim) has showed a high inhibition level against influenza A virus strains in vitro. The aim of this work is to search and establish evidence of the direct effect of the drug on influenza A virus pr...