Semimechanistic Pharmacodynamic Modeling of Aztreonam‐Avibactam Combination to Understand Its Antimicrobial Activity Against Multidrug‐Resistant Gram‐Negative Bacteria

• Main Authors: Alexia Chauzy (Author), Bruna Gaelzer Silva Torres (Author), Julien Buyck (Author), Boudewijn deJonge (Author), Christophe Adier (Author), Sandrine Marchand (Author), William Couet (Author), Nicolas Grégoire (Author)
• Format: Book
• Published: Wiley, 2019-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aztreonam‐avibactam (ATM‐AVI) is a promising combination to treat serious infections caused by multidrug‐resistant (MDR) pathogens. Three distinct mechanisms of action have been previously characterized for AVI: inhibition of ATM degradation by β‐lactamases, proper bactericidal effect, and enhanceme...