Bone Marrow-Derived CD44+ Cells Migrate to Tissue-Engineered Constructs via SDF-1/CXCR4-JNK Pathway and Aid Bone Repair

• Main Authors: Yanzhu Lu (Author), Junchao Xing (Author), Xiaolong Yin (Author), Xiaobo Zhu (Author), Aijun Yang (Author), Jiyue Luo (Author), Jing Gou (Author), Shiwu Dong (Author), Jianzhong Xu (Author), Tianyong Hou (Author)
• Format: Book
• Published: Hindawi Limited, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background and Aims. Host-derived cells play crucial roles in the regeneration process of tissue-engineered constructs (TECs) during the treatment of large segmental bone defects (LSBDs). However, their identity, source, and cell recruitment mechanisms remain elusive. Methods. A complex model was cr...