Population Pharmacokinetic Study of Benzylpenicillin in Critically Unwell Adults

• Main Authors: Reya V. Shah (Author), Karin Kipper (Author), Emma H. Baker (Author), Charlotte I. S. Barker (Author), Isobel Oldfield (Author), Barbara J. Philips (Author), Atholl Johnston (Author), Jeffrey Lipman (Author), Andrew Rhodes (Author), Marina Basarab (Author), Mike Sharland (Author), Sarraa Almahdi (Author), Rachel M. Wake (Author), Joseph F. Standing (Author), Dagan O. Lonsdale (Author)
• Format: Book
• Published: MDPI AG, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pharmacokinetics are highly variable in critical illness, and suboptimal antibiotic exposure is associated with treatment failure. Benzylpenicillin is a commonly used beta-lactam antibiotic, and pharmacokinetic data of its use in critically ill adults are lacking. We performed a pharmacokinetic stud...