Xiaochaihu decoction induces Bel-7402/5-FU cell apoptosis and autophagy via PI3K/AKT/mTOR pathway

• Main Authors: Xuejun Zhang (Author), Shilan Chen (Author), Xuejiao Wang (Author), Jiao Peng (Author), Jiumao Lin (Author), Jinyan Zhao (Author)
• Format: Book
• Published: KeAi Communications Co., Ltd., 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: This study aimed to observe the inhibitory effects of xiaochaihu decoction (XCHD) on human hepatocellular carcinoma (HCC) cells resistant to 5-fluorouracil (5-FU) (Bel-7402/5-FU) in vitro and in vivo and investigate its possible mechanisms. Methods: Bel-7402 ​cells and their resistant cel...