Enhanced Solubility and Biological Activity of Dexibuprofen-Loaded Silica-Based Ternary Solid Dispersions

• Main Authors: Muhammad Asim (Author), Marriam Nazir (Author), Zunera Chauhdary (Author), Muhammad Irfan (Author), Syed Haroon Khalid (Author), Sajid Asghar (Author), Usra (Author), Raed I. Felimban (Author), Mohammed A Majrashi (Author), Mohannad S. Hazzazi (Author), Mohammed Alissa (Author), Safa H Qahl (Author), Ghulam Hussain (Author), Azhar Rasul (Author), Shahzad Ali Shahid Chatha (Author), Ikram Ullah Khan (Author)
• Format: Book
• Published: MDPI AG, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The current study was designed to formulate ternary solid dispersions (TSDs) of dexibuprofen (Dex) by solvent evaporation to augment the solubility and dissolution profile, in turn providing gastric protection and effective anti-inflammatory activity. Initially, nine formulations (S1 to S9) of binar...