Effects of Tocilizumab on Inflammation and Iron Metabolism in Critically Ill Patients with COVID-19

• Main Authors: Robert Szabo (Author), Cristina Petrișor (Author), Constantin Bodolea (Author), Vlad Dobre (Author), Sebastian Tranca (Author), Simona Clichici (Author), Iulia Szabo (Author), Razvan Marian Melinte (Author), Teodora Mocan (Author)
• Format: Book
• Published: MDPI AG, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

COVID-19 produces cytokine-mediated persistent inflammation and is associated with elevated iron stores and low circulating iron. It is believed that central to the pathophysiological mechanism is interleukin 6 and hepcidin. A state of iron overload, termed hyperferritinemia, and inflammatory anemia...