A bridging assay for detection and characterization of anti-drug antibodies to dostarlimab, a new anti-PD-1 therapeutic monoclonal antibody

• Main Authors: Marilyn Patterson (Author), Lee Anne Beausang (Author), Bonita Rup (Author), Ronald R. Bowsher (Author), Kim Krug (Author), Murad Melhem (Author), Sharon Lu (Author)
• Format: Book
• Published: SpringerOpen, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Dostarlimab (JEMPERLI) is a humanized anti-programmed death 1 (PD-1) immunoglobulin (Ig)G4-kappa monoclonal antibody that binds to the PD-1 receptor and competitively inhibits binding of its ligands, PD-L1 and PD-L2. Dostarlimab was recently approved in the USA and the European Union. Becau...