pH as a potential therapeutic target to improve temozolomide antitumor efficacy : A mechanistic modeling study
Abstract Despite intensive treatments including temozolomide (TMZ) administration, glioblastoma patient prognosis remains dismal and innovative therapeutic strategies are urgently needed. A systems pharmacology approach was undertaken to investigate TMZ pharmacokinetics‐pharmacodynamics (PK‐PD) inco...
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| Main Authors: | , |
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| Format: | Book |
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Wiley,
2019-02-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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