Development and Optimization of Nanolipid-Based Formulation of Diclofenac Sodium: In Vitro Characterization and Preclinical Evaluation

• Main Authors: Ameeduzzafar Zafar (Author), Nabil K Alruwaili (Author), Syed Sarim Imam (Author), Mohd Yasir (Author), Omar Awad Alsaidan (Author), Ali Alquraini (Author), Alenazy Rawaf (Author), Bader Alsuwayt (Author), Md. Khalid Anwer (Author), Sultan Alshehri (Author), Mohammed M. Ghoneim (Author)
• Format: Book
• Published: MDPI AG, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In the present research study, we formulate bilosomes (BMs) of diclofenac (DC) for oral delivery for enhancement of therapeutic efficacy (anti-inflammatory disease). The BMS were prepared by thin film hydration method and optimized by Box-Behnken design (BBD) using cholesterol (A), lipid (B), surfac...