Potent dual block to HIV-1 infection using lentiviral vectors expressing fusion inhibitor peptide mC46- and Vif-resistant APOBEC3G

• Autores principales: Krista A. Delviks-Frankenberry (Autor), Chet R. Ojha (Autor), Kip J. Hermann (Autor), Wei-Shau Hu (Autor), Bruce E. Torbett (Autor), Vinay K. Pathak (Autor)
• Formato: Libro
• Publicado: Elsevier, 2023-09-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Gene therapy strategies that effectively inhibit HIV-1 replication are needed to reduce the requirement for lifelong antiviral therapy and potentially achieve a functional cure. We previously designed self-activating lentiviral vectors that efficiently delivered and expressed a Vif-resistant mutant...