Branched glycopolymer prodrug-derived nanoassembly combined with a STING agonist activates an immuno-supportive status to boost anti-PD-L1 antibody therapy

• Main Authors: Zhilin Li (Author), Qianfeng Zhang (Author), Zhiqian Li (Author), Long Ren (Author), Dayi Pan (Author), Qiyong Gong (Author), Zhongwei Gu (Author), Hao Cai (Author), Kui Luo (Author)
• Format: Book
• Published: Elsevier, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Despite the great potential of anti-PD-L1 antibodies for immunotherapy, their low response rate due to an immunosuppressive tumor microenvironment has hampered their application. To address this issue, we constructed a cell membrane-coated nanosystem (mB4S) to reverse an immunosuppressive microenvir...