Spatial Distribution of Mycobacterium ulcerans in Buruli Ulcer Lesions: Implications for Laboratory Diagnosis.

• Main Authors: Marie-Thérèse Ruf (Author), Miriam Bolz (Author), Moritz Vogel (Author), Pierre F Bayi (Author), Martin W Bratschi (Author), Ghislain Emmanuel Sopho (Author), Dorothy Yeboah-Manu (Author), Alphonse Um Boock (Author), Thomas Junghanss (Author), Gerd Pluschke (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Current laboratory diagnosis of Buruli ulcer (BU) is based on microscopic detection of acid fast bacilli, quantitative real-time PCR (qPCR), histopathology or cultivation. Insertion sequence (IS) 2404 qPCR, the most sensitive method, is usually only available at reference laboratories. Th...