Differential Blood-Brain Barrier Transport and Cell Uptake of Cyclic Peptides In Vivo and In Vitro

• Auteurs principaux: Erik Melander (Auteur), Camilla Eriksson (Auteur), Sara Wellens (Auteur), Kimia Hosseini (Auteur), Robert Fredriksson (Auteur), Fabien Gosselet (Auteur), Maxime Culot (Auteur), Ulf Göransson (Auteur), Margareta Hammarlund-Udenaes (Auteur), Irena Loryan (Auteur)
• Format: Livre
• Publié: MDPI AG, 2023-05-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

The blood-brain barrier (BBB) poses major challenges to drug delivery to the CNS. SFTI-1 and kalata B1 are cyclic cell-penetrating peptides (cCPPs) with high potential to be used as scaffolds for drug delivery. We here studied their transport across the BBB and distribution within the brain to gauge...