Differential Blood-Brain Barrier Transport and Cell Uptake of Cyclic Peptides In Vivo and In Vitro

• Main Authors: Erik Melander (Author), Camilla Eriksson (Author), Sara Wellens (Author), Kimia Hosseini (Author), Robert Fredriksson (Author), Fabien Gosselet (Author), Maxime Culot (Author), Ulf Göransson (Author), Margareta Hammarlund-Udenaes (Author), Irena Loryan (Author)
• Format: Book
• Published: MDPI AG, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The blood-brain barrier (BBB) poses major challenges to drug delivery to the CNS. SFTI-1 and kalata B1 are cyclic cell-penetrating peptides (cCPPs) with high potential to be used as scaffolds for drug delivery. We here studied their transport across the BBB and distribution within the brain to gauge...