Evidence of Pyrimethamine and Cycloguanil Analogues as Dual Inhibitors of <i>Trypanosoma brucei</i> Pteridine Reductase and Dihydrofolate Reductase

• Main Authors: Giusy Tassone (Author), Giacomo Landi (Author), Pasquale Linciano (Author), Valeria Francesconi (Author), Michele Tonelli (Author), Lorenzo Tagliazucchi (Author), Maria Paola Costi (Author), Stefano Mangani (Author), Cecilia Pozzi (Author)
• Format: Book
• Published: MDPI AG, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<i>Trypanosoma</i> and <i>Leishmania</i> parasites are the etiological agents of various threatening neglected tropical diseases (NTDs), including human African trypanosomiasis (HAT), Chagas disease, and various types of leishmaniasis. Recently, meaningful progresses in the t...