Cytochrome P450-Based Drug-Drug Interactions of Vonoprazan In Vitro and In Vivo

• Main Authors: Yiran Wang (Author), Changxiong Wang (Author), Shuanghu Wang (Author), Quan Zhou (Author), Dapeng Dai (Author), Jihua Shi (Author), Xue Xu (Author), Qingfeng Luo (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundVonoprazan fumarate is a potassium-competitive acid blocker that was developed as a novel acid-suppressing drug for multiple indications. As a potential alternative to proton-pump inhibitors, the determination of the drug-drug interactions is vital for further applications. Probe drug cock...