Lipopolysaccharide Inhibits the Channel Activity of the P2X7 Receptor

• Main Authors: Elias Leiva-Salcedo (Author), Claudio Coddou (Author), Felipe E. Rodríguez (Author), Antonello Penna (Author), Ximena Lopez (Author), Tanya Neira (Author), Ricardo Fernández (Author), Mónica Imarai (Author), Miguel Rios (Author), Jorge Escobar (Author), Margarita Montoya (Author), J. Pablo Huidobro-Toro (Author), Alejandro Escobar (Author), Claudio Acuña-Castillo (Author)
• Format: Book
• Published: Hindawi Limited, 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The purinergic P2X7 receptor (P2X7R) plays an important role during the immune response, participating in several events such as cytokine release, apoptosis, and necrosis. The bacterial endotoxin lipopolysaccharide (LPS) is one of the strongest stimuli of the immune response, and it has been shown t...