Synthesis and Biological Evaluation of a Series of Novel 1-(3-((6-Fluoropyridin-3-yl)oxy)propyl)piperazines as Dopamine/Serotonin Receptor Agonists

• Main Authors: Xin-Li Du (Author), Yan-Na Ni (Author), Jiang-Rong Ji (Author), Ze-Hong Wan (Author), Zhi-Jing Hu (Author), Yu-Qiang Ge (Author), Jian-Qi Li (Author), Guan Wang (Author)
• Format: Book
• Published: Georg Thieme Verlag KG, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Evidence suggested that the use of partial dopamine D2/D3 receptor agonists may be a better choice for the treatment of Parkinson's disease (PD), and the stimulation of 5-HT1A receptors (mainly via nondopaminergic mechanisms) alleviates motor and nonmotor disorders of PD, implying that...