SOX2-dependent expression of dihydroorotate dehydrogenase regulates oral squamous cell carcinoma cell proliferation

• Main Authors: Xuemei Qiu (Author), Sheng Jiang (Author), Yanxuan Xiao (Author), Yumin He (Author), Tao Ren (Author), Lu Jiang (Author), Rui Liu (Author), Qianming Chen (Author)
• Format: Book
• Published: Nature Publishing Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary Oral squamous cell carcinoma (OSCC) become a heavy burden of public health, with approximately 300 000 newly diagnosed cases and 145 000 deaths worldwide per year. Nucleotide metabolism fuel DNA replication and RNA synthesis, which is indispensable for cell proliferation. But how tumor cells...