Physiological implications of NTBI uptake by T lymphocytes

• Main Authors: Jorge P Pinto (Author), João eArezes (Author), Vera eDias (Author), Susana eOliveira (Author), Inês eVieira (Author), Mónica eCosta (Author), Matthijn eVos (Author), Anna eCarlsson (Author), Yuri eRikers (Author), Maria eRangel (Author), Graça ePorto (Author)
• Format: Book
• Published: Frontiers Media S.A., 2014-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In iron overload disorders a significant fraction of iron circulates in the plasma as low molecular weight complexes not bound to transferrin, known as non-transferrin-bound iron (NTBI). By catalyzing the formation of free radicals, NTBI accumulation results in oxidative stress and cellular damage c...