Frataxins Emerge as New Players of the Intracellular Antioxidant Machinery

• Główni autorzy: Ana Belén Uceda (Autor), Josefa Donoso (Autor), Juan Frau (Autor), Bartolomé Vilanova (Autor), Miquel Adrover (Autor)
• Format: Książka
• Wydane: MDPI AG, 2021-02-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Frataxin is a mitochondrial protein which deficiency causes Friedreich's ataxia, a cardio-neurodegenerative disease. The lack of frataxin induces the dysregulation of mitochondrial iron homeostasis and oxidative stress, which finally causes the neuronal death. The mechanism through which fratax...