Roles of Na+/H+ Exchanger Type 1 and Intracellular pH in Angiotensin II-Induced Reactive Oxygen Species Generation and Podocyte Apoptosis

• Main Authors: Ya Liu (Author), Hirofumi Hitomi (Author), Suwarni Diah (Author), Kazushi Deguchi (Author), Hirohito Mori (Author), Tsutomu Masaki (Author), Daisuke Nakano (Author), Hiroyuki Kobori (Author), Akira Nishiyama (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A growing body of evidence suggests that podocyte apoptosis is a major cause of decreased podocyte number, which leads to albuminuria and glomerular injury. The aim of this study was to clarify the molecular mechanisms of angiotensin II (Ang II)-induced apoptosis in cultured mouse podocytes. We exam...