Prolyl-hydroxylase inhibitors reconstitute tumor blood vessels in mice

• Main Authors: Shunji Nishide (Author), Junji Uchida (Author), Shinji Matsunaga (Author), Kentaro Tokudome (Author), Takehiro Yamaguchi (Author), Kazuya Kabei (Author), Taiki Moriya (Author), Katsuyuki Miura (Author), Tatsuya Nakatani (Author), Shuhei Tomita (Author)
• Format: Book
• Published: Elsevier, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tumor blood vessels have leaky and low blood flow properties, which lead to hypoxia and low nutrient levels in the tumor tissue area known as the tumor microenvironment (TME). We reported that the prolyl-hydroxylase (PHD) inhibitor Roxadustat normalized tumor blood vessels, improved tumor tissue per...