Eugenol and lidocaine inhibit voltage-gated Na+ channels from dorsal root ganglion neurons with different mechanisms

• Päätekijät: Luiz Moreira-Junior (Tekijä), Jose Henrique Leal-Cardoso (Tekijä), Antonio Carlos Cassola (Tekijä), Joao Luis Carvalho- (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Frontiers Media S.A., 2024-06-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Eugenol (EUG) is a bioactive monoterpenoid used as an analgesic, preservative, and flavoring agent. Our new data show EUG as a voltage-gated Na+ channel (VGSC) inhibitor, comparable but not identical to lidocaine (LID). EUG inhibits both total and only TTX-R voltage-activated Na+ currents (INa) reco...