Atenolol reduces Leishmania major-induced hyperalgesia and TNF-alpha without affecting IL-1beta or keratinocyte derived chemokines (KC)

• Main Authors: Marc eKaram (Author), Rana eMerkabawi (Author), Sara eSalman (Author), Ali eMobasheri (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Infection with a high dose of the intracellular parasitic protozoan L. major induces a sustained hyperalgesia in susceptible BALB/c mice accompanied by up-regulation of the pro-inflammatory cytokines IL-1β and IL-6. Interleukin-13 (IL-13) has been shown to reduce this hyperalgesia (despite increased...