Glibenclamide-Loaded Engineered Nanovectors (GNVs) Modulate Autophagy and NLRP3-Inflammasome Activation

• Main Authors: Marina Saresella (Author), Chiara Paola Zoia (Author), Francesca La Rosa (Author), Chiara Bazzini (Author), Gessica Sala (Author), Erica Grassenis (Author), Ivana Marventano (Author), Ambra Hernis (Author), Federica Piancone (Author), Elisa Conti (Author), Silvia Sesana (Author), Francesca Re (Author), Pierfausto Seneci (Author), Carlo Ferrarese (Author), Mario Clerici (Author)
• Format: Book
• Published: MDPI AG, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Activation of the NLRP3 inflammasome in response to either exogenous (PAMPs) or endogenous (DAMPs) stimuli results in the production of IL-18, caspase-1 and IL-1β. These cytokines have a beneficial role in promoting inflammation, but an excessive activation of the inflammasome and the consequent con...