PCSK9 Regulates Nox2-Mediated Platelet Activation via CD36 Receptor in Patients with Atrial Fibrillation

• Main Authors: Vittoria Cammisotto (Author), Daniele Pastori (Author), Cristina Nocella (Author), Simona Bartimoccia (Author), Valentina Castellani (Author), Cinzia Marchese (Author), Antonio Sili Scavalli (Author), Evaristo Ettorre (Author), Nicola Viceconte (Author), Francesco Violi (Author), Pasquale Pignatelli (Author), Roberto Carnevale (Author)
• Format: Book
• Published: MDPI AG, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: High levels of proprotein convertase subtilisin/kexin 9 (PCSK9) is predictive of cardiovascular events (CVEs) in atrial fibrillation (AF). We hypothesized that PCSK9 may directly induce platelet activation (PA). Methods: We measured platelet aggregation, recruitment, Thromboxane B2 (TxB2...