Effects of Metformin on Burn-Induced Hepatic Endoplasmic Reticulum Stress in Male Rats

• Main Authors: Yaeko Hiyama (Author), Alexandra H. Marshall (Author), Robert Kraft (Author), Nour Qa'aty (Author), Anna Arno (Author), David N. Herndon (Author), Marc G. Jeschke (Author)
• Format: Book
• Published: BMC, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Severe burn injury causes hepatic dysfunction that results in major metabolic derangements including insulin resistance and hyperglycemia and is associated with hepatic endoplasmic reticulum (ER) stress. We have recently shown that insulin reduces ER stress and improves liver function and m...