Normothermic Ex Vivo Heart Perfusion with Mesenchymal Stem Cell-Derived Conditioned Medium Improves Myocardial Tissue Protection in Rat Donation after Circulatory Death Hearts

• Main Authors: Zifeng Zeng (Author), Liwei Xu (Author), Yu Xu (Author), Yongsheng Ruan (Author), Deshen Liu (Author), Jiale Li (Author), Chuanjie Niu (Author), Shaoyi Zheng (Author), Pengyu Zhou (Author), Zezhou Xiao (Author)
• Format: Book
• Published: Hindawi Limited, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective. Adopting hearts from donation after circulatory death (DCD) is a promising approach to enlarge the donor pool. Nevertheless, DCD hearts experience severe warm ischemia/reperfusion (I/R) injury. Recent studies have demonstrated that conditioned medium (CM) derived from bone marrow mesenchy...