Exploring the Metabolism of Loxoprofen in Liver Microsomes: The Role of Cytochrome P450 and UDP-Glucuronosyltransferase in Its Biotransformation

• Main Authors: Riya Shrestha (Author), Pil Joung Cho (Author), Sanjita Paudel (Author), Aarajana Shrestha (Author), Mi Jeong Kang (Author), Tae Cheon Jeong (Author), Eung-Seok Lee (Author), Sangkyu Lee (Author)
• Format: Book
• Published: MDPI AG, 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Loxoprofen, a propionic acid derivative, non-steroidal anti-inflammatory drug (NSAID) is a prodrug that is reduced to its active metabolite, trans-alcohol form (Trans-OH) by carbonyl reductase enzyme in the liver. Previous studies demonstrated the hydroxylation and glucuronidation of loxoprofen. How...