Implementation of Systematic Bioanalysis of Antibody-Drug Conjugates for Preclinical Pharmacokinetic Study of Ado-Trastuzumab Emtansine (T-DM1) in Rats

• Auteurs principaux: Eun-Jeong Jeon (Auteur), Ju-Hee Han (Auteur), Youjin Seo (Auteur), Eun Mi Koh (Auteur), Kang-Hyun Han (Auteur), Kyunghwa Hwang (Auteur), Kyung Jin Jung (Auteur)
• Format: Livre
• Publié: MDPI AG, 2023-02-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Antibody-drug conjugates (ADCs) are composed of monoclonal antibodies covalently bound to cytotoxic drugs by a linker. They are designed to selectively bind target antigens and present a promising cancer treatment without the debilitating side effects of conventional chemotherapies. Ado-trastuzumab...