Development of Novel Small-Molecule Activators of Pyruvate Kinase Muscle Isozyme 2, PKM2, to Reduce Photoreceptor Apoptosis

• Main Authors: Thomas J. Wubben (Author), Sraboni Chaudhury (Author), Brennan T. Watch (Author), Jeanne A. Stuckey (Author), Eric Weh (Author), Roshini Fernando (Author), Moloy Goswami (Author), Mercy Pawar (Author), Jason C. Rech (Author), Cagri G. Besirli (Author)
• Format: Book
• Published: MDPI AG, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Treatment options are lacking to prevent photoreceptor death and subsequent vision loss. Previously, we demonstrated that reprogramming metabolism via the pharmacologic activation of PKM2 is a novel photoreceptor neuroprotective strategy. However, the features of the tool compound used in those stud...