Extracellular matrix stiffness controls cardiac valve myofibroblast activation through epigenetic remodeling

• मुख्य लेखकों: Cierra J. Walker (लेखक), Dilara Batan (लेखक), Carrie T. Bishop (लेखक), Daniel Ramirez (लेखक), Brian A. Aguado (लेखक), Megan E. Schroeder (लेखक), Claudia Crocini (लेखक), Jessica Schwisow (लेखक), Karen Moulton (लेखक), Laura Macdougall (लेखक), Robert M. Weiss (लेखक), Mary A. Allen (लेखक), Robin Dowell (लेखक), Leslie A. Leinwand (लेखक), Kristi S. Anseth (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Wiley, 2022-09-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract Aortic valve stenosis (AVS) is a progressive fibrotic disease that is caused by thickening and stiffening of valve leaflets. At the cellular level, quiescent valve interstitial cells (qVICs) activate to myofibroblasts (aVICs) that persist within the valve tissue. Given the persistence of my...