Extracellular matrix stiffness controls cardiac valve myofibroblast activation through epigenetic remodeling

• Main Authors: Cierra J. Walker (Author), Dilara Batan (Author), Carrie T. Bishop (Author), Daniel Ramirez (Author), Brian A. Aguado (Author), Megan E. Schroeder (Author), Claudia Crocini (Author), Jessica Schwisow (Author), Karen Moulton (Author), Laura Macdougall (Author), Robert M. Weiss (Author), Mary A. Allen (Author), Robin Dowell (Author), Leslie A. Leinwand (Author), Kristi S. Anseth (Author)
• Format: Book
• Published: Wiley, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Aortic valve stenosis (AVS) is a progressive fibrotic disease that is caused by thickening and stiffening of valve leaflets. At the cellular level, quiescent valve interstitial cells (qVICs) activate to myofibroblasts (aVICs) that persist within the valve tissue. Given the persistence of my...