Extracellular matrix stiffness controls cardiac valve myofibroblast activation through epigenetic remodeling

• Главные авторы: Cierra J. Walker (Автор), Dilara Batan (Автор), Carrie T. Bishop (Автор), Daniel Ramirez (Автор), Brian A. Aguado (Автор), Megan E. Schroeder (Автор), Claudia Crocini (Автор), Jessica Schwisow (Автор), Karen Moulton (Автор), Laura Macdougall (Автор), Robert M. Weiss (Автор), Mary A. Allen (Автор), Robin Dowell (Автор), Leslie A. Leinwand (Автор), Kristi S. Anseth (Автор)
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• Опубликовано: Wiley, 2022-09-01T00:00:00Z.
• Предметы: article
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Abstract Aortic valve stenosis (AVS) is a progressive fibrotic disease that is caused by thickening and stiffening of valve leaflets. At the cellular level, quiescent valve interstitial cells (qVICs) activate to myofibroblasts (aVICs) that persist within the valve tissue. Given the persistence of my...