Synthetic mRNA delivered to human cells leads to expression of Cpl-1 bacteriophage-endolysin with activity against Streptococcus pneumoniae

• Main Authors: Moritz K. Jansson (Author), Dat Tien Nguyen (Author), Stefan Mikkat (Author), Carolin Warnke (Author), Marc Benjamin Janssen (Author), Philipp Warnke (Author), Bernd Kreikemeyer (Author), Nadja Patenge (Author)
• Format: Book
• Published: Elsevier, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Endolysins are bacteriophage-encoded hydrolases that show high antibacterial activity and a narrow substrate spectrum. We hypothesize that an mRNA-based approach to endolysin therapy can overcome some challenges of conventional endolysin therapy, namely organ targeting and bioavailability. We show t...