The distinguishing NS5-M114V mutation in American Zika virus isolates has negligible impacts on virus replication and transmission potential.

• Main Authors: Nias Y G Peng (Author), Alberto A Amarilla (Author), Leon E Hugo (Author), Naphak Modhiran (Author), Julian D J Sng (Author), Andrii Slonchak (Author), Daniel Watterson (Author), Yin Xiang Setoh (Author), Alexander A Khromykh (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

During 2015-2016, outbreaks of Zika virus (ZIKV) occurred in Southeast Asia and the Americas. Most ZIKV infections in humans are asymptomatic, while clinical manifestation is usually a self-limiting febrile disease with maculopapular rash. However, ZIKV is capable of inducing a range of severe neuro...