The role of ERK-1 and ERK-2 gene polymorphisms in PCOS pathogenesis

• Main Authors: Gurhan Guney (Author), Mine Islimye Taşkın (Author), Nazli Sener (Author), Ezgi Tolu (Author), Yavuz Dodurga (Author), Levent Elmas (Author), Orkun Cetin (Author), Cengiz Sarigul (Author)
• Format: Book
• Published: BMC, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Ovulation is regulated by extracellular signal-regulated kinase-1 (ERK-1) and ERK-2 signaling mechanisms, and ERK-1/2 kinases modulates the function of most of the LH-regulated genes. Defective ERK kinase signaling that is secondary to a genetic problem contributes to both ovulat...