Crystal structure of the human carbonic anhydrase II adduct with 1-(4-sulfamoylphenyl-ethyl)-2,4,6-triphenylpyridinium perchlorate, a membrane-impermeant, isoform selective inhibitor

Pyridinium containing sulfonamides have been largely investigated as carbonic anhydrase inhibitors (CAIs), showing interesting selectivity features. Nevertheless, only few structural studies are so far available on adducts that these compounds form with diverse CA isoforms. In this paper, we report...

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Main Authors: Vincenzo Alterio (Author), Davide Esposito (Author), Simona Maria Monti (Author), Claudiu T. Supuran (Author), Giuseppina De Simone (Author)
Format: Book
Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
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