Crystal structure of the human carbonic anhydrase II adduct with 1-(4-sulfamoylphenyl-ethyl)-2,4,6-triphenylpyridinium perchlorate, a membrane-impermeant, isoform selective inhibitor

• Auteurs principaux: Vincenzo Alterio (Auteur), Davide Esposito (Auteur), Simona Maria Monti (Auteur), Claudiu T. Supuran (Auteur), Giuseppina De Simone (Auteur)
• Format: Livre
• Publié: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Pyridinium containing sulfonamides have been largely investigated as carbonic anhydrase inhibitors (CAIs), showing interesting selectivity features. Nevertheless, only few structural studies are so far available on adducts that these compounds form with diverse CA isoforms. In this paper, we report...