Cepharanthine synergistically promotes methylprednisolone pharmacodynamics against human peripheral blood mononuclear cells possibly via regulation of P-glycoprotein/glucocorticoid receptor translocation

• Main Authors: Wencheng Xu (Author), Shuhe Chen (Author), Xiaoqin Wang (Author), Jinwen Min (Author), Sachiko Tanaka (Author), Kenji Onda (Author), Kentaro Sugiyama (Author), Haruki Yamada (Author), Toshihiko Hirano (Author)
• Format: Book
• Published: BMC, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Cepharanthin® alone or in combination with glucocorticoid (GC) has been used to treat chronic immune thrombocytopenia (ITP) since the 1990s. Cepharanthine (CEP) is one of the main active components of Cepharanthin®. The purpose of this study was to investigate the effects of CEP...