Creation and preliminary characterization of a Tp53 knockout rat

• Main Authors: Aaron McCoy (Author), Cynthia L. Besch-Williford (Author), Craig L. Franklin (Author), Edward J. Weinstein (Author), Xiaoxia Cui (Author)
• Format: Book
• Published: The Company of Biologists, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY The tumor suppressor TP53 plays a crucial role in cancer biology, and the TP53 gene is the most mutated gene in human cancer. Trp53 knockout mouse models have been widely used in cancer etiology studies and in search for a cure of cancer with some limitations that other model organisms might...