Loss of Tropomodulin4 in the zebrafish mutant träge causes cytoplasmic rod formation and muscle weakness reminiscent of nemaline myopathy

• Автори: Joachim Berger (Автор), Hakan Tarakci (Автор), Silke Berger (Автор), Mei Li (Автор), Thomas E. Hall (Автор), Anders Arner (Автор), Peter D. Currie (Автор)
• Формат: Книга
• Опубліковано: The Company of Biologists, 2014-12-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Nemaline myopathy is an inherited muscle disease that is mainly diagnosed by the presence of nemaline rods in muscle biopsies. Of the nine genes associated with the disease, five encode components of striated muscle sarcomeres. In a genetic zebrafish screen, the mutant träge (trg) was isolated base...