HIV Progression Perturbs the Balance of the Cell-Mediated and Anti-Inflammatory Adaptive and Innate Mycobacterial Immune Response

• Main Authors: Andrew R. DiNardo (Author), Anna M. Mandalakas (Author), Gugu Maphalala (Author), Godwin Mtetwa (Author), Temhlanga Mndzebele (Author), Piluca Ustero (Author), Makhosazana Hlatshwayo (Author), Emily M. Mace (Author), Jordan S. Orange (Author), George Makedonas (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction. Our objective is to understand how HIV infection increases the risk of progression from latent tuberculosis (TB) to active disease. We understand now that immunity is a balance of competing immune responses by multiple cell types. Since T-lymphocyte production of interferon-gamma (IFN-...